Premature babies: ‘Most will do very well,’ says expert

Premature babies: ‘Most will do very well,’ says expert


Written by Yella Hewings-Martin, Ph.D. on November 17, 2020

When babies are born prematurely, caregivers and hospital staff rightly worry. However, as Dr. Mercurio, a professor of neonatology from Yale School of Medicine, explains, ‘the outcomes will be good’ for most of these babies.


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Premature babies are born before 37 weeks of pregnancy. Each year, this is the case for about 15 million babies across the world and 10% of babies born in the United States.

For caregivers, a premature birth and the time spent in the hospital afterward can be exceedingly worrying and stressful.

But the care of premature babies has improved immensely in the last 50 years.

In this Special Feature interview to mark Prematurity Awareness Month, Medical News Today spoke to Dr. Mark Mercurio, a professor of pediatrics (neonatology) and the chief of Neonatal-Perinatal Medicine at Yale School of Medicine in New Haven, CT.

Dr. Mercurio is also the director of the Program for Biomedical Ethics and the director of the Yale Pediatrics Ethics Program.

In this interview, Dr. Mercurio explains why taking care of premature babies is challenging, how this care has changed during his career, and what research he is keen to see. He also tells us what he wants caregivers of premature babies to know.

We have lightly edited the interview transcript for clarity.

Better equipment and a better understanding

Medical News Today: What are the biggest challenges that healthcare professionals face in the care of premature babies?

Dr. Mercurio: There are many challenges, really, but we could break these down into the technical and medical challenges and then the psychological and ethical aspects.

There are technical challenges in part just because the patients are so small.

This can make things more difficult. For example, most people are familiar with the fact that sometimes it can be hard to place an IV in an adult or an older child. So you can imagine the technical difficulties in someone who weighs just a pound or two.

In terms of the medical aspects, every organ system is immature.

A primary example is the lungs. The challenge is to ensure that enough oxygen can get into the blood via the lungs, and this is often much more difficult with premature, underdeveloped lungs. To accomplish this, there are various modes of assisted ventilation that might be needed.

In the brain, there is a possibility of injury because the baby is born very early. That has to do with the immaturity of the brain structurally at the time of delivery and possibly further injury during the intensive care course.

We know that premature babies, especially those born extremely premature, are at increased risk for long-term problems with brain function.

A third example would be the gastrointestinal system, which is also immature. So, getting adequate nutrition into these children can sometimes be a challenge.

MNT: How has the care of premature babies changed during your career, and what has made the biggest impact on this?

Dr. Mercurio: The care of premature babies has changed in many ways over the course of my career.

We are constantly evaluating the data. We are constantly evaluating outcomes. There are controlled trials [happening all the time] to establish which is the better way to [provide care].

So, care evolves based on the new data, based on the outcomes of the studies that we do, and that is always a work in progress. Neonatology, like all of medicine, is rightfully always changing as we learn more.

I think we ventilate babies very differently. For example, the use of respiratory support for babies with immature lungs has evolved significantly over the course of my career and has gotten much better.

We have better equipment, and we also have a better understanding of how to go about it.

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